BDC-1001 continues to have a favorable safety and tolerability profile with mild (grade 1/grade 2) infusion related reactions in some patients and no dose-limiting toxicities at dose levels up to 20 mg/kg every three weeks and 12 mg/kg every two weeks. Fifty-seven subjects have been treated at increasing dose levels up to 20 mg/kg every three weeks and 12 mg/kg every two weeks, and data from these subjects demonstrate that: The poster presentation at ESMO I-O reported new safety, pharmacokinetic/pharmacodynamic, and efficacy results for the ongoing Phase 1 dose-escalation portion of the BDC-1001 monotherapy trial. “There is a clear need for well tolerated, durable treatments in the fight against cancer and I’m excited to see if BDC-1001 can deliver on that potential as we explore higher drug exposure levels.” Sharma, Associate Director of Clinical Research at START Midwest. “The favorable safety profile and early indications of clinical disease control in the BDC-1001 study are encouraging,” said Dr. BDC-1001 is an immune-stimulating antibody conjugate (ISAC) comprising a HER2-targeting biosimilar of trastuzumab conjugated with a non-cleavable linker to an innovative TLR7/8 agonist. BDC-1001 demonstrated a favorable safety and tolerability profile at all evaluated doses and schedules, showing early signs of clinical activity with corresponding biomarker changes in the tumor microenvironment of post-treatment tumor biopsies. The company reported data from 57 subjects participating in an ongoing Phase 1/2 study of BDC-1001, across 16 different types of HER2-expressing solid tumors. The lead author for the poster is Manish Sharma, M.D., START Midwest, with contributions from Ecaterina Dumbrava, M.D., MD Anderson Cancer Center, and other colleagues from the U.S. (Nasdaq: BOLT), a clinical-stage biotechnology company pioneering a new class of immuno-oncology agents that combine the targeting precision of antibodies with the power of both the innate and adaptive immune systems, today announced the presentation of interim clinical data from the company’s ongoing Phase 1/2 study of BDC-1001, the company’s lead immune-stimulating antibody conjugate (ISAC) in a poster session at the European Society for Medical Oncology Immuno-Oncology (ESMO I-O) Congress 2021, being held virtually from Dec. 06, 2021 (GLOBE NEWSWIRE) - Bolt Biotherapeutics, Inc. Live conference call and webcast today at 8:00 a.m. In the end, SAFC were unlucky in penalty kicks, falling 5-3 to Orange County from the spot.Company to continue monotherapy dose-escalation and evaluate weekly dose regimenĬombination dose-escalation study of BDC-1001 with Opdivo® on target to initiate by year end 2021 The two teams ended regular time tied and would go on to play an eventful but scoreless extra 30 minutes. Maloney’s assist was his second in the postseason, which is a new SAFC record. The goal was Epps’ seventh of the season in all competitions and first in the playoffs. A run from Connor Maloney down the right hand side ended with a pinpoint cross to the back post where Marcus Epps leaped highest to finish. 
It only took 20 minutes in the second half for SAFC to equalize.
SAFC entered halftime down a goal and looking to get back into the match in the second 45 minutes. It was the home side that would strike first when a long throw from the hosts found the foot of the leading scorer Ronaldo Damus who finished past the diving Jordan Farr. The match started relatively even with both teams feeling the other out to try and get a foothold in the game. Everybody needs to keep their head held high and be proud of what was achieved this year, and to have reached a Western Conference Final for the first time in franchise history.” “We clearly demonstrated a true team identity, and I'm proud of everybody's effort and commitment. They were ultra-competitive and demonstrated resilience throughout the season. “It's tough to go out on penalties, but I'm proud of the collective and how cohesive they were. It was an amazing season,” said SAFC Head Coach Alen Marcina.
After falling behind in the first half, SAFC leveled in the second half and took the game to penalty kicks where they were eventually eliminated.
San Antonio FC had its playoff dream fall just short after a gritty and hardworking performance on the road in Orange County in the Western Conference Finals on Saturday night.
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